Diabetic Fibrous Mastopathy: Imaging Features With Histopathologic Correlation

Abstract Diabetic fibrous mastopathy (DFM) is a rare benign fibrotic disease of the breast that develops in patients with longstanding and often uncontrolled diabetes mellitus. Clinically, may present an irregular, firm, palpable mass, which be solitary or multiple, occurring one both breasts. occurs most premenopausal women heterogeneously extremely dense breasts; mammography show focal asymmetry or, less often, noncalcified mass indistinct obscured margins, but there are usually no discrete findings. On US, DFM have marked hypoechogenicity posterior shadowing secondary to extensive fibrosis. features on contrast-enhanced MRI also nonspecific, gradual persistent nonmass enhancement reported. Because clinical presentation US overlap those cancer, histopathologic correlation needed confirm diagnosis exclude malignancy. These findings include collagenous stroma keloidal chronic perilobular perivascular inflammation. Histopathologic lymphocytic lobulitis inflammation common other autoimmune conditions.